Thermo-responsive, on-demand adhesive and tissue-conformal hydrogel electrodes for organ repair and brain-computer interfaces.

ABSTRACT: Implantable bioelectronic devices, such as brain-computer interfaces (BCIs), face persistent challenges in achieving stable, rapid, and reversible adhesion on wet tissues due to hydration layers and mechanical mismatch, which can cause interfacial failure and unstable signals. Here, we report a conductive hydrogel interface with tissue-adaptive, temperature-controllable adhesion. The material is synthesized via dynamic co-entanglement of poly(acrylic acid) and poly(lipoic acid) with LA-NHS, establishing a dual physico-chemical anchoring mechanism that enables efficient tissue integration in aqueous environments. The hydrogel penetrates tissue microstructures within 5 s, withstands burst pressures >213 mmHg, exhibits <10 % swelling, ∼2784 % extensibility, and a low modulus of 41 kPa, thereb

SUBMITTER: Li Z 

PROVIDER: S-EPMC12813216 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature