Associations between structural brain alterations and dysfunction across cognitive domains in cerebral small vessel disease: A systematic review and meta-analysis.

ABSTRACT: Cerebral small vessel disease (CSVD) is a primary contributor to vascular cognitive impairment. Although extensive research has examined white matter alterations in CSVD, cortical mechanisms underlying cognitive dysfunction remain incompletely characterized. To address this gap, we conducted a systematic review and meta-analysis of 26 studies investigating whether structure-cognition relationships in CSVD could be interpreted through biologically defined functional brain networks. By mapping structural features to the Yeo-7 functional atlas, we offer a network-based perspective on cognitive impairment in this population. Our integrated results demonstrate significant associations between structural alterations and all cognitive domains in CSVD patients. Notably, higher-order cognitive proc

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12813308 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature