Picosecond laser-engineered osteon-inspired concentric micropatterns on titanium implants regulate cellular behaviour to facilitate osseointegration.

ABSTRACT: Achieving successful osseointegration in dental implants remains challenging due to biological and biomechanical complications. Inspired by the architecture of osteons, the fundamental structural units of cortical bone, this study employs picosecond-ultraviolet laser (PSL-UV) technology to create biomimetic, osteon-like concentric micropatterns with varying groove widths (20 μm, 40 μm, 60 μm, and 80 μm) on titanium (Ti) surfaces. These patterns aim to regulate cellular behavior and enhance osseointegration. In vitro studies demonstrated that groove width critically influenced cellular responses: 20 μm and 80 μm patterns significantly enhanced osteoblast activity while simultaneously regulating or suppressing osteoclast and fibroblastic activity. Gene expression and omics analyses fu

SUBMITTER: Yie KHR 

PROVIDER: S-EPMC12813317 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature