Innovative Y-shaped hydrogel mitral clip with magnetic actuation and hydrophilic janus surface for enhanced valve leaflet repair.

ABSTRACT: We developed a magnetically responsive Y-shaped hydrogel mitral clip for minimally invasive repair of mitral regurgitation. Fabricated through a multilayer assembly strategy, the clip integrates a polyurethane layer featuring a biomimetic inverse opal architecture to enhance tissue adhesion, a GelMA/Fe₃O₄ hydrogel for magnetic actuation, a flexible epoxy acrylate scaffold for mechanical compliance, and a biocompatible polydimethylsiloxane interface. The clip exhibits Janus wettability, with a hydrophilic inner surface to promote effective leaflet anchoring and a hydrophobic outer surface to minimize blood fouling, thus optimizing device-tissue and device-fluid interactions. Performance was validated through in vitro, ex vivo, and computational studies, confirming prec

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12813318 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature