A multifunctional hyaluronic acid hydrogel with pH-responsive metformin release for accelerated healing of diabetic infected wounds.

ABSTRACT: Diabetic wounds remain a global public-health threat due to simultaneous bleeding, bacterial colonization and persistent inflammation. We hypothesized that a dynamic metal-polyphenol hydrogel that instantly seals bleeding vessels, acid-triggered releases metformin and synergistically photothermal antibacterial would break this deadlock. Therefore, we developed a multifunctional hyaluronic acid hydrogel (ODF-Met) by conjugating metformin to dopamine-grafted oxidized hyaluronic acid via dynamic imine bonds, followed by coordination with Fe³⁺ to form a dynamic metal-polyphenol network. This unique structure endows ODF-Met with remarkable photothermal antibacterial efficacy (≈100 %), self-healing ability, biodegradability and robust tissue adhesion (30 kPa). Importantly, ODF-Met exh

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC12813348 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature