Nanozyme antibiotic dressings to accelerate wound healing through anti-inflammatory and antibacterial effects.

ABSTRACT: Chronic and refractory wounds pose significant clinical challenges due to persistent bacterial colonization, excessive inflammation, and impaired tissue regeneration. Herein, we report a multifunctional hydrogel, CuHP@GelMA, integrating CuHP nanozyme with GelMA, which combines cascade multienzyme-mimetic catalytic activity, antibacterial efficacy, anti-inflammatory function, and tissue regenerative potential. The CuHP nanozymes exhibit peroxidase (POD)-like activity to generate reactive oxygen species (ROS) for bacterial membrane disruption, alongside superoxide dismutase (SOD)- and catalase (CAT)-like activities to modulate oxidative stress, effectively mitigating inflammation and cellular damage. Encapsulation within the GelMA hydrogel ensures controlled release and reduced cytotoxicity,

SUBMITTER: Wang X 

PROVIDER: S-EPMC12813355 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature