Therapeutic nanoliposome vaccine targeting multiple Aβ and tau epitopes reduces AD-like brain pathologies and rescues cognitive deficits in 3xTg-AD mice.

ABSTRACT: Amyloid beta (Aβ) plaques and hyperphosphorylated tau neurofibrillary tangles (NFTs) are the histopathological hallmarks of Alzheimer's disease (AD) and targets for AD therapeutics. Since Aβ and tau pathologies both drive AD pathogenesis and progression, immunotherapies singularly targeting either Aβ or tau may be limited, and simultaneously targeting multiple epitopes of both Aβ and tau may be an efficacious approach. We developed a novel vaccine including three his-tagged tau peptides, tau_1-22, mid-region tau_171-191 (tau_pT181), and tau_388-407 (tau_pS396/S404), as well as two his-tagged Aβ fragments (N-terminal Aβ_1-14 and N-terminal pyroglutamate Aβ_pE3-14) with the spontaneous nanoliposome antigen particle (SNAP)

SUBMITTER: Dai CL 

PROVIDER: S-EPMC12813361 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature