Vascular graph network for ovarian lesion classification using optical-resolution photoacoustic microscopy.

ABSTRACT: Diagnosing ovarian lesions is challenging because of their heterogeneous clinical presentations. Some benign ovarian conditions, such as endometriosis, can have features that mimic cancer. We use optical-resolution photoacoustic microscopy (OR-PAM) to study the differences in ovarian vasculature between cancer and various benign conditions. In this study, we converted OR-PAM vascular data into vascular graphs augmented with physical vascular properties. From 94 ovarian specimens, a custom vascular graph network (VGN) was developed to classify each graph as either normal ovary, one of three benign pathologies, or cancer. We demonstrated for the first time that, by leveraging the intrinsic similarity between vascular networks and graph constructs, VGN provides stable predictions from samplin

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12813362 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature