Microfluidic 3D-printed MSC-laden bioactive hydrogel for intrauterine adhesion prevention and endometrial regeneration.

ABSTRACT: Increasing occurrence of intrauterine adhesion (IUA) is a serious threat to the reproductive health of women in recent years. However, treatment options remain limited. Mesenchymal stem cell (MSC)-based therapies have shown a promising regenerative capacity of injured endometrium but have limited effectiveness by the low survival duration of transplanted cells. Herein, we present a bioactive hydrogel scaffold loaded with adipose tissue-derived MSC (AT-MSC) by using a three-dimensional (3D) bioprinting technology, which combines the characteristics of the synthetic thermos-responsive material PF-127 and the natural-derived, photo-polymerizable material GelMA. The composite hydrogel scaffold shows enhanced mechanical as well as biocompatibility. In addition, the porous structure endows the 3

SUBMITTER: Song Y 

PROVIDER: S-EPMC12813364 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature