Frequency of HLA class I and II in an admixed Brazilian population with psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic, immune-mediated disease with a significant genetic component. The HLA-C*06:02 allele is one of the most strongly associated with the disease, particularly influencing early onset and severity. There are few current data on genetics in a Brazilian population with psoriasis.

Objective

This study aimed to investigate the genetic associations between human leucocyte antigen (HLA) alleles and psoriasis in a Brazilian admixed population.

Methods

The authors conducted HLA class I and II genotyping in 144 patients with psoriasis and compared the results with those of 720 controls. Additionally, the authors calculated the Psoriasis Area and Severity Index (PASI) and recorded whether the patient had current or previous systemic treatment for p

SUBMITTER: Sampaio AL 

PROVIDER: S-EPMC12813529 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature