Muscle Imaging in Inclusion Body Myositis: Refinement of MRI Criteria and Insights Into Upper Body Involvement.

ABSTRACT:

Background

The diagnosis of inclusion body myositis (IBM) can be delayed because of its heterogeneous clinical presentation and the lack of specific biomarkers. Muscle imaging has gained increasing relevance over the past decade and is now included among the supportive criteria in the international diagnostic guidelines. This study aimed to refine MRI criteria for IBM to facilitate clearer pattern recognition, increase their reproducibility and broader clinical applicability. We also aimed to provide a comprehensive evaluation of muscle wasting across the entire body, including less frequently assessed regions such as the neck, scapular girdle and trunk muscles, and to explore the presence of radiological IBM phenotypes through cluster analysis.

Methods

Sixty-eight MRI scans

SUBMITTER: Torchia E 

PROVIDER: S-EPMC12813550 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature