Regulation of ferroptosis in colorectal cancer through therapeutic modulation and miRNA targeting.

ABSTRACT: Colorectal cancer (CRC) is a highly prevalent disease that represents a major global health burden. Ferroptosis has gained significant attention in recent years as a potential target for cancer therapy. Meanwhile, microRNAs (miRNAs) have emerged as key regulators of gene expression, with the potential to influence various cellular pathways and functions, including those involved in cancer development and treatment. In this study, we employed a systems biology approach to leverage the FerrDb database and to identify key genes involved in the ferroptosis pathway. Then, we utilized the NCBI Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs) associated with ferroptosis in CRC. The miRNet platform was used to identify miRNAs that target ferroptosis-associated genes

SUBMITTER: Ahmadizad Firouzjaei A 

PROVIDER: S-EPMC12813574 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature