Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.

ABSTRACT:

Context

Neurodegenerative diseases are particularly prevalent among patients with acromegaly, but their functional alterations remain poorly understood.

Objective

To explore the neurobiological mechanisms of excess growth hormone (GH) on brain functional activity and connectivity in acromegaly.

Methods

Neuropsychological assessments and resting-state functional magnetic resonance imaging (fMRI) were conducted on 27 patients with acromegaly and 25 healthy controls. The amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared between groups via voxel-based analyses, while graph theory was used to assess brain network topology. T-tests and multikernel support vector machine (MK-SVM) were used to identify discr

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12813690 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature