Non-invasive MRI of choroid plexus-cerebrospinal fluid water exchange using multi-TE FLAIR.

ABSTRACT: The choroid plexus (CP), or blood-cerebrospinal fluid barrier, performs unique and diverse roles in support of brain homeostasis. Novel and non-invasive imaging biomarkers of choroid plexus physiology may be useful to further our understanding of its role in the development of pathology. Here, we introduce the concept of measuring water exchange between the choroid plexus tissue and the proximal CSF using a multiple TE fluid-suppressed (FLAIR) acquisition. By fitting the MRI signal at the choroid plexus acquired with a multi-TE FLAIR readout to a two-compartment bi-exponential model, we observed that the slow decaying T2 component of the signal had a T2 highly similar to that of cerebrospinal fluid (CSF). This finding, in turn, provides evidence that, paradoxically, this signal derives fro

SUBMITTER: Nizari S 

PROVIDER: S-EPMC12813853 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature