FMRI signals of pattern separation in the neocortex and hippocampus to non-meaningful objects and their spatial location.

ABSTRACT: Computational theories of memory posit that the dentate gyrus and CA3 (CA3DG) hippocampal subfields reduce mnemonic interference via a process called pattern separation. While the CA3DG is viewed as a domain-general pattern separator, the parahippocampal and perirhinal cortices may play a role in content-specific (e.g., spatial or object-related) interference reduction. Recent work suggests that frontal and parietal control areas may allocate resources during mnemonic discrimination, but the evidence is still limited. Moreover, mnemonic discrimination tasks designed for humans almost exclusively use everyday items as stimuli, confounding retrieval processes with pattern separation. To address these challenges, we acquired high-resolution structural images of the medial temporal lobe, and f

SUBMITTER: Nemecz Z 

PROVIDER: S-EPMC12813878 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature