3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification.

ABSTRACT: The harsh microenvironment characterized by avascularity and hypoxia presents a significant challenge for bone regeneration following refractory bone defects. Tissue engineering combined with electrotherapy has emerged as a promising alternative for repairing bone defects, offering advantages such as accelerated healing and the restoration of physiological functions in regenerated bone. In this study, we propose a strategy for constructing tissue-engineered cartilage derived from bone marrow stem cells (BMSCs) for bone regeneration, utilizing 3D-printed triboelectric scaffolds (TES). The TES scaffold is fabricated from biodegradable bioelastomer and conductive biomaterial, featuring excellent biomimetic elasticity and hydrophobicity. The TES contains numerous hydrophobic microporous units,

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12813882 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature