Multiscale Three-Dimensional Vertical Graphene-Encapsulated Nanoparticle Coatings for Antibacterial Applications against Multidrug-Resistant Bacteria.

ABSTRACT: Implant-associated infections caused by multidrug-resistant Staphylococcus aureus (S. aureus) remain a major clinical challenge, underscoring the urgent need for surface-engineered antibacterial strategies that extend beyond conventional antibiotic delivery. Here, we report a hierarchical antimicrobial coating that integrates chemical surface functionalization, nanoparticle (NP) assembly, vertical graphene (VG) growth, and antibiotic incorporation into a hybrid platform. The resulting three-dimensional composite coating (Si/APTES/NPs/VG) features a NP-mediated interfacial layer and vertically oriented graphene with a high drug-loading capacity, enabling localized, contact-mediated antibacterial activity. The Si/APTES/NPs/VG/vancomycin coating exhibited potent antibacterial ef

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12813970 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature