Beyond Mimicking Enzymes: NewTAML/Peroxide Abstracts sp³ C-H Bonds to Initiate Biotranscendent Water-Purifying Mineralization of Fluoroquinolone Antibiotics.

ABSTRACT: In neutral aqueous media under ambient temperature, the bis-amido-bis-sulfonamido-ligated [Fe^III{4-NO₂C₆H₃-1,2-(NCOCMe₂NSO₂)₂CHMe}(OH₂)]^- NewTAML catalyst (2), activates hydrogen peroxide to mimic and greatly surpass enzymatic activity (biotranscendence) by sweeping fluoroquinolone antibiotics rapidly toward minerals. Stepwise identification of intermediates was paired with mechanistic examination of key steps. For ofloxacin, the 2/H₂O₂ activated catalyst (AC) first attacks ofloxacin's piperazine unit in two enzyme-mimicking parallel pathways, cleaving secondary (desaturation) and primary (N-demethylation) sp³ C-H bonds via H

SUBMITTER: Ma X 

PROVIDER: S-EPMC12814164 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature