A Divergent Asymmetric Total Synthesis of Coprophilin and Four Trichodermic Acids via a [1,5]-Hydride Shift-Aldol Cascade.

ABSTRACT: The asymmetric syntheses of coprophilin and four members of the trichodermic acid family of natural products are disclosed. Our work employs a number of key transformations, including an aluminum-promoted [1,5]-hydride shift-aldol cascade reaction, an exo-selective Diels-Alder cycloaddition, and a late-stage Fleming-Tamao oxidation. These key steps efficiently construct the bicyclic core of the natural products, which can then be readily functionalized in a divergent manner, allowing the synthesis of a wide range of natural product targets.

SUBMITTER: Smith E 

PROVIDER: S-EPMC12814181 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature