Crystal Surface Reactivity of Esterase@Zeolitic Imidazolate Framework Biocomposites.

ABSTRACT: Esterase@zeolitic imidazolate framework (Esterase@ZIF) biocomposites have been synthesized by biomineralization of pig liver esterase to explore the synergistic interplay between esterase and the ZIF framework on crystal surface reactivity and biocompatibility. The targeted Esterase@ZIF crystal phases cover a wide range of ZIF topologies, namely, Zn(mIm)₂ (ZIF-8, 3D sodalite, microporous, mImH = 2-methylimidazole), Zn(mIm)₂·(mImH)_0.5 (ZIF-L, 2D layered, nonporous), and Zn(mIm)(CO₃)_0.5 (ZIF-C, 3D, nonporous). As model reactions, we have assessed the hydrolytic decontamination of the G-type nerve agent simulant diisopropylfluorophosphate (DIFP) and esterase activity toward indoxyl acetate hydrolysis. The results show a clear synergistic

SUBMITTER: Borrego-Marin E 

PROVIDER: S-EPMC12814183 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature