Stereoselective palladium-catalyzed carboetherification of cyclopropenes <i>via</i> a tethering strategy.

ABSTRACT: Highly functionalized cyclopropanes are often sought after chemical motifs as building blocks in synthetic and medicinal chemistry. However, their stereoselective synthesis using catalytic methods remains a challenge. Herein we report the first carboetherification of cyclopropenes using a palladium-catalyzed tethering strategy. This reaction was compatible with various functional groups, and could be performed using aryl, alkynyl and vinyl coupling partners. The carboetherification proceeded in a stereoselective manner imparted by the trifluoromethylated tether and afforded pentasubstituted spirocyclopropanes as single diastereoisomers, extending significantly the scope of metal-catalyzed difunctionalization of strained alkenes. This process could be easily scaled up to a gram scale, and p

SUBMITTER: Brownsey DK 

PROVIDER: S-EPMC12814203 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature