Comparing Rotational Thromboelastometry and Standard Coagulation Assays for Predicting Intraoperative Bleeding in Pediatric Liver Transplantation.

ABSTRACT:

Background

Utility of preoperative rotational thromboelastometry (ROTEM) over standard coagulation assays (SCAs) in predicting intraoperative bleeding during orthotopic liver transplantation (OLT) in children with liver failure (LF) remains unclear.

Methods

In this single-center retrospective cohort of pediatric OLT recipients, we compared the predictive values of preoperative ROTEM parameters (intrinsic pathway (INTEM) maximum clot firmness (MCF), extrinsic pathway (EXTEM) clotting time (CT), INTEM CT, and fibrinogen-based (FIBTEM) MCF) and the corresponding SCAs (platelet count, international normalized ratio (INR), activated partial thromboplastin time (aPTT), and fibrinogen level, respectively) for significant intraoperative bleeding (blood loss of > 22 mL/kg; i.e., ≥ 85

SUBMITTER: Deshotels K 

PROVIDER: S-EPMC12814310 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature