Electrochemical Hydrogenation of Aza-Arenes Using H₂O as H Source.

ABSTRACT: Electrochemical hydrogenation of aza-arenes is an appealing strategy to gain access to privileged saturated heterocycles for drug discovery, overcoming the limitations of classical hydrogenations that often suffer from energy-intensive conditions and safety hazards. Herein, we demonstrate an operationally simple, sustainable, and general electrochemical hydrogenation of aza-arenes with commercialized Ni foam electrodes and setup. With water as the hydrogen donor under acidic conditions, the reaction proceeds at ambient temperature and pressure to deliver broad substrate generality, excellent functional group tolerance, and excellent selectivity. The method tolerates a wide range of aza-arenes─including (iso)quinolines, quinoxalines, pyridines, and their nium salts─highlighting its generali

SUBMITTER: Dutta S 

PROVIDER: S-EPMC12814348 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature