Persistent effects of early-life arsenic exposure in <i>Caenorhabditis elegans</i>.

ABSTRACT: Arsenic exposure is a major global health challenge. In addition to well-documented toxic effects in exposed people and animals, there is evidence that exposure to arsenic may lead to transgenerational effects. Transgenerational effects of low levels of exposure are challenging to study in species with long generation times. The model organism Caenorhabditis elegans offers the ability to quickly carry out transgenerational experiments with very large sample sizes of isogenic animals, reducing variation, and numerous biological replicates, to increase statistical rigor. An important challenge historically associated with this species for such work is uncertainty about internal dosimetry and toxicokinetics. Here, we report a 4-generation experiment in which C. elegans were expo

SUBMITTER: Hershberger KA 

PROVIDER: S-EPMC12814376 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature