Chemoselective Synthesis of δ-Amino Alcohols from Chiral 1,4-Diols Catalyzed by an NHC-Ir(III) Complex.

ABSTRACT: The synthesis of δ-amino alcohols from 1,4-diols via the hydrogen borrowing strategy by an NHC-Ir(III) catalyst is described. The amination occurs on the primary alcohol selectively. The mild, base-free conditions effectively suppress the common second intramolecular amination to pyrrolidines. sec-Alcohols, even benzylic ones, remain inert toward amination and even without racemization, enabling the synthesis of chiral δ-amino alcohols from readily available chiral 1,4-diols. Late-stage functionalization (LSF) of Lenalidomide and other complex drugs is demonstrated.

SUBMITTER: Silvi E 

PROVIDER: S-EPMC12814538 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature