Advanced Catalysts for Olefin Synthesis: Copper(II) Quinoline-Fused Oxazolidines in Alcohol Dehydration.

ABSTRACT: The new copper(II) catalyst [Cu(^QFOX)(CH₃CN)][OTf]₂ has been synthesized and found to be active for alcohol dehydration to give olefins at 120 °C with a 1% catalyst loading (^QFOX = di-2-quinolinyl-fused-oxazolidine). Benzylic, allylic, and tertiary alcohols are all dehydrated. In some cases, ethers are observed to be produced, but these are re-entrained into the catalytic cycle. Unactivated secondary alcohols are also dehydrated. Similar catalysts employing Mn^II, Fe^II, Co^II, and Ni^II were also synthesized but showed reduced dehydration activity compared to the copper(II) derivative. A Cu^I analog was also prepared but did not show improved dehydration activity.

SUBMITTER: Panda A 

PROVIDER: S-EPMC12814556 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature