Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation.

ABSTRACT:

Background

Microplastics have been repeatedly detected in the human body, yet uncertainties surround their bioavailability and fate due to experimental challenges and limitations, especially regarding their nano-sized counterparts. Knowing that toxicokinetics information is essential for accurate risk assessment and management, this research aimed to (1) evaluate different sample preparation and quantification methods for nanoplastics particles in mammalian tissue, and (2) investigate the lung retention, bioavailability and fate of these particles.

Methods

In this study, rats inhaled aerosols with up to 50 mg/m³ of Nile Red-labeled polystyrene (PS-NR) or unlabeled polyamide particles (PA-6) particles for 28 days. The tissues were analyzed for the presence of polym

SUBMITTER: Tha E 

PROVIDER: S-EPMC12814592 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature