Bioactive metabolites from cultures of the entomopathogenic fungus <i>Pleurocordyceps ophiocordycipiticola</i> TBRC-BCC 9612.

ABSTRACT: Pleurocordyceps ophiocordycipiticola TBRC-BCC 9612, an entomopathogenic fungus collected from Khao Yai National Park, Thailand, was investigated for its secondary metabolites. Large-scale fermentation, followed by multistep chromatographic separation, resulted in the isolation of seven new compounds, including an ergot-type alkaloid (dihydroergopleurine, 2), three tetramic acid derivatives (pleurocordines A-C, 4-6), two acyclic terpenoids (7 and 8), and a dihydroisobenzofuran derivative (9), along with twelve known compounds. The structures of the new compounds were elucidated based on spectroscopic analyses, including 1D and 2D NMR, HRMS, and ECD data. Selected compounds were evaluated for antimalarial activity against Plasmodium falciparum K1, antibacterial activity against

SUBMITTER: Saepua S 

PROVIDER: S-EPMC12814817 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature