Sophora flavescens seed reinforces chicken cecal barrier against Eimeria tenella.

ABSTRACT: Eimeria tenella (E. tenella) causes severe coccidiosis in chickens, leading to bloody diarrhea, growth retardation, high mortality, and substantial economic losses. Rising drug resistance and residue concerns limit conventional chemical anticoccidials, driving interest in Traditional Chinese Medicine as a safe, cost-effective, and sustainable alternative. To investigate the effects of Sophora flavescens seed extract (SFSE) on E. tenella-infected chicken ceca, 12-day-old chickens were assigned to control, infection, and SFSE groups, with the latter two orally inoculated with sporulated E. tenella oocysts on day 14. Samples were collected at 5- and 7-days post-infection (DPI). Cecal histopathology was assessed with HE and Masson's trichrome staining. DNA damage was detected by TUNEL assay. G

SUBMITTER: Tian E 

PROVIDER: S-EPMC12814843 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature