Genetic evaluation of early-onset atrial fibrillation: impact on patient management.

ABSTRACT:

Background and aims

Genetic testing is recommended for select patients with atrial fibrillation (AF). The aims of this study were to define the results of genetic evaluation and its therapeutic impact for patients referred to a dedicated AF precision medicine clinic.

Methods

Patients diagnosed with AF before age 60 were candidates for referral. In addition to standard evaluation with history, physical exam, and electrocardiogram (ECG), genetic evaluation included a three-generation pedigree, cardiac imaging, ambulatory monitoring, and clinical genetic testing with a cardiomyopathy/arrhythmia panel.

Results

Overall, 264 participants were referred: the median age was 47 years (Q1, Q3: 38, 55), 77 (29%) were female, and 236 (89%) were White. Median age at AF diagnosis wa

SUBMITTER: Laws JL 

PROVIDER: S-EPMC12814854 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature