Development and validation of predictive models for 6-month gastrostomy timing in amyotrophic lateral sclerosis.

ABSTRACT:

Background

Dysphagia is common in amyotrophic lateral sclerosis (ALS), contributing to malnutrition and accelerated disease progression. Although early nutritional intervention is recommended, the optimal timing for percutaneous endoscopic gastrostomy (PEG) placement remains uncertain. This study aimed to develop and validate simple prediction models, accessible via an online calculator, to identify ALS patients likely to require PEG within 6 months.

Methods

We conducted a retrospective cohort study including ALS patients followed at three Italian reference centres between February 2018 and October 2023. Predictors of PEG placement within 6 months were identified using univariate and multivariable binary logistic regression models. Prediction models were developed following

SUBMITTER: Lizio A 

PROVIDER: S-EPMC12815051 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature