Associations of body weight and COVID-19 with autoimmunity in pediatric new-onset type 1 diabetes: results from the prospective DPV registry.

ABSTRACT:

Introduction

This study analyzed the effects of the COVID-19 pandemic and body weight on islet and endocrine autoimmunity in children with type 1 diabetes (T1D).

Research design and methods

Data from 11 973 children and adolescents aged 0.5 to <18 years with new-onset T1D (2015-2023) from the Diabetes Prospective Follow-up Registry were evaluated. Rates of autoantibodies against beta cells (islet antigen 2 (IA2), zinc transporter 8 (ZnT8), glutamic acid decarboxylase (GAD), insulin), thyroid, transglutaminase (TGA), and adrenals were assessed. Logistic regression models adjusted for age and sex examined associations with COVID-19 and body mass index (BMI).

Results

6136 (51%) children were diagnosed with T1D before, and 5837 (49%) after the beginning of the COVID-19 pa

SUBMITTER: Boettcher C 

PROVIDER: S-EPMC12815073 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature