Impact of anticancer drugs on human Tenon's fibroblast proliferation: implications for glaucoma surgery.

ABSTRACT:

Objective

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma and the primary target of current therapies. When IOP-lowering drugs are insufficient, surgical intervention may be required; however, conjunctival and subconjunctival scarring often limits long-term success. Although intraoperative and postoperative antimetabolite treatments help preserve surgical outcomes, they are associated with ocular side effects. This study investigated the effects of selected anticancer drugs on the proliferation of human Tenon's fibroblasts (HTFs), key mediators of postoperative scarring.

Methods and analysis

Primary HTFs were isolated from explants obtained during glaucoma surgery and characterised by immunofluorescence. The cytotoxic effects of candidate drugs were a

SUBMITTER: Villa V 

PROVIDER: S-EPMC12815085 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature