From structural heart lesions to host burden: changing epidemiology and outcomes of native valve infective endocarditis, a nationwide study, 2006-2023.

ABSTRACT:

Background

The epidemiology of native valve infective endocarditis (IE) has shifted toward older adults with substantial comorbidity burdens, yet contemporary nationwide data on outcomes and surgical impact remain limited.

Methods

We conducted an 18-year nationwide cohort study of adults hospitalised with native valve IE in Korea (2006-2023). Outcomes included in-hospital and 5-year all-cause mortality, IE relapse and a composite of death or relapse. Temporal trends, mortality predictors and surgical associations across age strata were evaluated using multivariable Cox models and stratified survival analyses.

Results

Among 18 402 patients (mean age 63.7 years), incidence declined in individuals <45 years but increased in those ≥65 years. In-hospital mortality was 25.5

SUBMITTER: Kim DY 

PROVIDER: S-EPMC12815166 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature