Association of genetic variation with age at diagnosis in type 1 diabetes.

ABSTRACT:

Introduction

Type 1 diabetes is an autoimmune disease with a strong genetic basis. The aim of this study was to identify additional single-nucleotide polymorphisms (SNPs) for type 1 diabetes age at diagnosis and to replicate previously identified loci.

Research design and methods

Meta genome-wide association studies of age at diagnosis from eight cohorts (n=5910 in total) were performed in three models. Model 1 was age at diagnosis with no covariates. Model 2 was age at diagnosis adjusted for DR3/DR4 genotype categories. Model 3 was similar to model 2, including the most significant SNP from model 2 (coded additively). Models 1 and 2 were also performed for major histocompatibility complex (MHC) imputed data. In addition, we tested previously identified loci for age at diagn

SUBMITTER: Vollenbrock CE 

PROVIDER: S-EPMC12815190 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature