Does CMR improve aetiological sub-phenotyping beyond echocardiography in patients with elevated LV filling pressure? A prospective registry study (PREFER-CMR).

ABSTRACT:

Objectives

To evaluate the incremental diagnostic value and sub-phenotyping capability of Cardiovascular Magnetic Resonance (CMR) compared with Transthoracic Echocardiography (TTE) in patients with elevated left ventricular filling pressure (LVFP).

Design

Prospective registry study. [Results from ClinicalTrials.gov ID NCT05114785] SETTING: A single NHS hospital in the UK.

Main outcome measures

The primary outcome was the rate of diagnostic discordance between TTE and CMR. Secondary outcomes included the characterisation of specific pathologies identified by CMR where TTE was normal, non-diagnostic or provided a non-specific diagnosis.

Results

CMR demonstrated diagnostic discordance with TTE in 74% (n=194) of cases. In patients with a normal TTE (n=54), CMR iden

SUBMITTER: Bana A 

PROVIDER: S-EPMC12815195 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature