Behavioral and psychological symptoms of dementia associated with vascular impairment: a systematic review and meta-analysis.

ABSTRACT:

Objective

Vascular cognitive impairment (VCI) is a major cause of cognitive decline associated with vascular brain injury. Behavioral and psychological symptoms of dementia (BPSD) are common, but their prevalence across VCI subtypes remains unclear. This study examines the prevalence of BPSD in different VCI subtypes.

Methods

A systematic review and meta-analysis were conducted following PRISMA guidelines. Studies assessing BPSD in patients with VCI were retrieved from PubMed, Embase, and Web of Science. Studies were eligible if they used the Neuropsychiatric Inventory (NPI) to evaluate symptoms. Pooled prevalence rates for each NPI domain were calculated using a random-effects model.

Results

Thirty-five studies (n=5,805) were included. In unspecified VCI, apathy (54.

SUBMITTER: Santos AP 

PROVIDER: S-EPMC12815398 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature