Effects of sodium nitroprusside on the default mode network of patients with schizophrenia and healthy controls.

ABSTRACT:

Objective

Brain default mode network (DMN) function is altered in schizophrenia (SZ). Considering the roles of nitrergic and glutamatergic transmission in SZ neurobiology, supplementation with nitric oxide (NO) donors such as sodium nitroprusside (SNP) has been proposed as a means of reducing symptoms, but results have been mixed and potential mechanisms remain unclear. In this context, we sought to investigate the effects of SNP on DMN functional connectivity (FC) assessed by functional magnetic resonance imaging (fMRI) in SZ patients and healthy controls.

Methods

In an open-label trial, participants were divided into three treatment groups to receive intravenous SNP (0.25 µg/kg/min over 12 minutes): SZ patients on clozapine (CLZ) (n=13), SZ patients on non-CLZ antipsychoti

SUBMITTER: Garcia GJ 

PROVIDER: S-EPMC12815400 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature