Proton Beam Therapy for Untreated Hepatocellular Carcinoma Unsuitable for Transcatheter Arterial Chemoembolization.

ABSTRACT:

Introduction

Intermediate-stage hepatocellular carcinoma (HCC) derives limited benefit from transarterial chemoembolization (TACE), which has led to introduction of the concept of "TACE-unsuitable HCC." Drug therapy may be more beneficial, but intrahepatic lesion control tends to be a problem. Particle therapy including proton beam therapy (PBT) provides high local control (LC) with minimal toxicity, even in advanced cases. On this study, we retrospectively assessed the efficacy and safety of PBT in patients with TACE-unsuitable previously untreated HCC.

Methods

Between 2010 and 2018, 202 patients underwent definitive PBT for previously untreated HCC. TACE-unsuitable HCC was defined as one or more of the following; cases exceeding up-to-seven criteria, of ALBI grade 2-3, non

SUBMITTER: Niitsu H 

PROVIDER: S-EPMC12815477 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature