Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults.

ABSTRACT:

Objective

Anxiety disorders and subsyndromal anxiety symptoms are highly prevalent in late life. Recent studies support that anxiety may be a neuropsychiatric symptom during preclinical Alzheimer's disease (AD) and that higher anxiety is associated with more rapid cognitive decline and progression to cognitive impairment. However, the associations of specific anxiety symptoms with AD pathologies and with co-occurring subjective and objective cognitive changes have not yet been established.

Methods

Baseline data from the A4 and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration studies were analyzed. Older adult participants (n = 4,486) underwent assessments of anxiety (State-Trait Anxiety Inventory-6 item version [STAI]), and cerebral amyloid-beta (Aβ; ¹⁸

SUBMITTER: Lee S 

PROVIDER: S-EPMC12815479 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature