Changes in pain during buprenorphine maintenance treatment among patients with opioid use disorder and chronic pain.

ABSTRACT:

Objective

Opioid use disorder (OUD) and chronic pain frequently co-occur. Little is known about changes in pain during buprenorphine/naloxone (BUP/NX) maintenance and whether outcomes vary by pain levels. The present study examined changes in pain intensity and pain interference over 12 weeks of BUP/NX maintenance among participants with OUD and chronic pain (N = 194). Differences in outcomes were assessed during BUP/NX maintenance (Week 12) and 2 months following a BUP/NX taper (Week 24).

Method

Data from Phase 2 of the Prescription Opioid Addiction Treatment Study (POATS) were used. Two latent transition models were conducted to characterize profiles and transitions between profiles of pain intensity or pain interference (estimated separately).

Results

Each m

SUBMITTER: Edwards KA 

PROVIDER: S-EPMC12815489 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature