First-Generation Antihistamine Use in Geriatric Emergency Department Patients: Retrospective Review.

ABSTRACT:

Introduction

First-generation antihistamines are frequently used in the emergency department (ED) but are discouraged in older adults due to increased adverse drug effects. Whether concerns about adverse drug effects apply to the ED is uncertain, as ED-specific data are limited, and risks with single-dose administration may differ from risks with chronic use. In this study we assessed frequency of use, adverse drug effects, and indications of first-generation antihistamines administered to older adults during ED visits.

Methods

This retrospective cohort study identified adults ≥ 65 years of age who received first-generation antihistamines from January 1-December 31, 2022 in the ED at a single, urban, academic medical center. Abstractors blinded to study hypotheses identified

SUBMITTER: Killen E 

PROVIDER: S-EPMC12815559 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature