Enhanced Mott cell formation linked with IgM Fc receptor (FcμR) deficiency.

ABSTRACT: In previous studies, Mott cells, an unusual form of plasma cells containing Ig-inclusion bodies, were frequently observed in peripheral lymphoid tissues in our IgM Fc receptor (FcμR)-deficient (KO) mouse strain. Because of discrepancies in the reported phenotypes of different Fcmr KO mouse strains, we here examined two additional available mutant strains and confirmed that such enhanced Mott-cell formation was a general phenomenon associated with FcμR deficiency. Splenic B cells from Fcmr KO mice clearly generated more Mott cells than those from WT mice when stimulated in vitro with LPS alone or a B-1, but not B-2, activation cocktail. Nucleotide sequence analysis of the Ig variable regions of a single IgMλ⁺ Mott-hybridoma clone developed from splenic B-1 B cells of Fcmr KO mice

SUBMITTER: Mahmoudi Aliabadi P 

PROVIDER: S-EPMC12815582 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature