Demographic Trends in NCI-sponsored Early-phase Clinical Trials (2000-2023): A Cohort Study.

ABSTRACT: We analyzed demographic trends among patients enrolled in NCI Cancer Therapy Evaluation Program-sponsored early-phase clinical trials during 2000 to 2023. Using a large patient subset (N = 16,609; 15,308 U.S. residents), we assessed enrollment trends via 3-year rolling averages and Joinpoint analysis. U.S. residents were matched to census demographics, rurality, geographic, and poverty data by ZIP code and Surveillance, Epidemiology, and End Results 2022 cancer incidence rates. Enrollment increased among patients aged 65 to 74 (24.6%-32.3%) and 75 to 84 (6.2%-12.4%) and among Hispanic/Latino (4.5%-7.7%), Asian/Pacific Islander (2.2%-4.4%), and non-Hispanic Black (6.1%-7.2%) patients. However, participation remained below cancer incidence rates for Hispanic/Latino and non-Hispanic Black pat

SUBMITTER: Farooq M 

PROVIDER: S-EPMC12815584 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature