Impact of extent of surgical resection on survival in World Health Organization grade 4 gliomas: A molecular subtype-based analysis.

ABSTRACT:

Background

Extensive surgical resection is associated with longer survival in patients with glioma; however, the combined impact of surgical extent and molecular pathology on prognosis remains unclear. In this study, we evaluated how molecular pathology and clinical features influence surgical outcomes in patients with World Health Organization (WHO) grade 4 gliomas, including isocitrate dehydrogenase (IDH)-mutant astrocytomas and IDH wild-type glioblastomas.

Methods

Data from 501 patients with WHO grade 4 gliomas who underwent surgery were obtained from the Chinese Glioma Genome Atlas database (2005-2019). The effect of resection extent on overall survival was analyzed and stratified using molecular pathology and clinical characteristics. Survival differences were assessed

SUBMITTER: Hou Z 

PROVIDER: S-EPMC12815601 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature