Life's Essential 8 and the Risk of Overall and Specific-Site Cancer Types: A Large-Scale Prospective Cohort Study.

ABSTRACT:

Background

The Life's Essential 8 (LE8) framework, designed to prevent cardiovascular disease, is also linked to cancer risk, but the direct association between LE8 adherence and cancer incidence remains underexplored. Each LE8 component may affect cancer risk differently across organ systems, warranting further investigation into these relationships.

Methods

This prospective cohort study utilized data from the Kailuan Study, comprising 94,239 participants from Tangshan, China. LE8 scores were calculated based on lifestyle and physiological measures, including diet, physical activity, and biomarkers such as blood glucose and cholesterol levels. Incident cancer cases were monitored through biennial health assessments and verified through multiple data sources until December 3

SUBMITTER: Deng L 

PROVIDER: S-EPMC12815607 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature