A Real-World Analysis of Outcomes in CIC-Rearranged Sarcomas: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study.

ABSTRACT:

Introduction

CIC-rearranged sarcomas (CRS) are rare tumors predominantly affecting young adults. Despite distinct biology, CRS are often treated like Ewing sarcomas with multi-agent chemotherapy, surgery, and radiotherapy, although the benefits of each remain unclear. We report the impact of treatment on response and survival.

Methods

This retrospective multicenter study included patients diagnosed with CRS between 2002 and 2023. Demographic, treatment, and outcome data were collected. Event-free (EFS) and overall survival (OS) were estimated using Kaplan-Meier analysis; risk factors were assessed via log-rank tests and Cox regression. Treatment response was assessed using RECIST.

Results

Among 27 patients (median age 21.5 years; range 8-83), 14 (52%) had localized an

SUBMITTER: Wittmann Dayagi T 

PROVIDER: S-EPMC12815609 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature