Automated item-level measures of verbal fluency in semantic and logopenic primary progressive aphasia.

ABSTRACT:

Introduction

Verbal fluency tasks are widely used in primary progressive aphasia (PPA), but most studies rely only on total correct responses, overlooking qualitative features of the words produced. We applied a scalable computational framework to extract item-level features from fluency responses in semantic variant (svPPA) and logopenic variant PPA (lvPPA) to test their value for differential diagnosis.

Methods

We analyzed animal fluency responses from 113 participants (40 svPPA, 40 lvPPA, 33 controls) using an automated pipeline extracting nine psycholinguistic features. Group differences were examined with (co)variance models, classification with logistic regression, and brain-behavior associations via structural magnetic resonance imaging.

Results

All features ex

SUBMITTER: Vonk JMJ 

PROVIDER: S-EPMC12815610 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature