Identifying the state of cerebrovascular autoregulation using the pressure reactivity index versus the mean flow index: Why metric matters.

ABSTRACT: Cerebral autoregulation maintains stable cerebral blood flow despite fluctuations in cerebral perfusion pressure (CPP), through mechanisms that alter vascular diameter and resistance. Two commonly used indices, pressure reactivity index and mean flow index, reflect different aspects of this regulation, namely changes in cerebral blood volume and blood flow velocity. However, their interchangeability, particularly in the context of traumatic brain injury (TBI), remains questionable. This study investigates the frequency and physiological basis of discordance between these indices. Using 96 simultaneous recordings of intracranial pressure (ICP) and transcranial Doppler-derived flow velocity in TBI patients, 501 non-overlapping 20-minute segments were extracted. Each segment was classified ba

SUBMITTER: Olakorede I 

PROVIDER: S-EPMC12815637 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature