Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients.

ABSTRACT: Metastatic breast cancer (MBC) is generally an incurable neoplasm. A small cohort of patients with HER2-positive MBC, however, achieve such prolonged remission without relapse following anti-HER2 therapy and chemotherapy, that it is speculated they might be cured. The genomes of these patients might provide insights into the underlying mechanisms for their successful treatment. Here, a total of 243 HER2-positive patients diagnosed with MBC between 2000 and 2015 were studied. Of these, 29 patients were identified as exceptional responders (ExR) with an overall survival (OS) > 60 months and no evidence of relapse, 54 patients with an OS > 60 months but who relapsed or developed progressive disease were defined as exceptional survivors (ExS), and 160 patients with an OS < 60 months were ident

SUBMITTER: Andrieu C 

PROVIDER: S-EPMC12815647 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature